Dr. Lun-Ching Chang
Education
- Ph.D. in Biostatistics, University of Pittsburgh, 2014
Research Interests
I have a wide range of research interests related to Statistical Genetics, Bioinformatics, Computational Biology and Biostatistics. In methodological research, I focus on developing statistical method for Statistical Genetics (genotype calling and copy number variants detection) and meta-analysis of high-throughput data. In addition, I am also interest in collaborative research. I have many collaborative experience with researchers in different area such as clinical trial, psychiatry, computational biology and genetics.
Research Description
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Statistical Genetics
- Genotype calling method in sequencing data
- Copy number variants (CNVs) in whole exome sequencing (WES)
- Exon deletion in whole exome, whole genome and RNA-Seq
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Meta-analysis
- Meta-analysis of P-value combination and clustering analysis in microarray data set
- Integrative-omics study of SNP-array, methylation and gene expression
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Collaborative research
- Clinical trial
- Psychiatry (major depressive disorder, aging)
Recent Publications
- Wu, I-Wen, Lun-Ching Chang, Yi-Lun Wu, Huang-Yu Yang, Yuh-Ching Twu, Po-Yu Tsai, Skyler Paulus et al. "Gut flora metagenomic analysis coupled with metabolic and deep immune profiling in chronic kidney disease." Nephrology Dialysis Transplantation (2024): gfae013.
- Su, Shih-Chi, James E. Galvin, Shun-Fa Yang, Wen-Hung Chung, and Lun-Ching Chang. "wiSDOM: a visual and statistical analytics for interrogating microbiome." Bioinformatics 37, no. 17 (2021): 2795-2797.
- Galvin, J.E., Chrisphonte, S., Cohen, I., Greenfield, K.K., Kleiman, M.J., Moore, C., Riccio, M.L., Rosenfeld, A., Shkolnik, N., Walker, M. and Chang, L.C., 2021. Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD). Alzheimer's & dementia, 17(10), pp.1675-1686.
- Lin, Chien-Wei, Lun-Ching Chang, Tianzhou Ma, Hyunjung Oh, Beverly French, Rachel Puralewski, Fasil Mathews et al. "Older molecular brain age in severe mental illness." Molecular psychiatry 26, no. 7 (2021): 3646-3656.
- Song, Chi, Shih-Chi Su, Zhiguang Huo, Suleyman Vural, James E. Galvin, and Lun-Ching Chang. "HCMMCNVs: hierarchical clustering mixture model of copy number variants detection using whole exome sequencing technology." Bioinformatics 37, no. 18 (2021): 3026-3028.
- Full list: my google scholar (https://scholar.google.com/citations?user=89VEfigAAAAJ&hl=en )
